hrp0086p1-p444 | Fat Metabolism and Obesity P1 | ESPE2016

Neonatal Overfeeding Alters Hepatic Insulin Sensitivity During Lactation and Leads to Long-term Insulin Resistance and Fatty Liver in Mice: Key Role of Mogat1

Ramon-Krauel Marta , Pentinat Thais , Cebria Judith , Vila Maria , Perez-Wienese Ricky , Kalko Susana , Tietge Uwe , Plosch Torsten , Diaz Ruben , Jimenez-Chillaron Josep

Background: Excessive energy intake and rapid weight gain early in life are associated with obesity, type 2 diabetes, hepatic steatosis and other features of the metabolic syndrome. The monoacylglycerol acyltransferase (MGAT) is an enzyme involved in an alternative pathway for triglyceride (TAG) synthesis and storage. It has been recently proposed to have potential implications in the pathogenesis of hepatic insulin resistance (IR).Objective: To understa...